ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

Page 1 of about 2 results

ey0019.14-5 | Steroidogenesis and beyond | ESPEYB19

14.5. Embryonic osteocalcin signalling determines lifelong adrenal steroidogenesis and homeostasis in the mouse

VK Yadav , JM Berger , P Singh , P Nagarajan , G Karsenty

J Clin Invest 2022;132(4):e153752 doi: 10.1172/JCI153752Brief summary: Using rodent and primate models, this study shows a classical endocrine feedback loop, where bone-derived osteocalcin enhances adrenal steroidogenesis, and the inactivation of osteocalcin signalling impairs adrenal growth and steroidogenesis.This study provides important evidence on the existence of the bo...
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ey0016.5-18 | Basic Science - Bone | ESPEYB16

5.18. Developmental origin, functional maintenance and genetic rescue of osteoclasts

CE Jacome-Galarza , GI Percin , JT Muller , E Mass , T Lazarov , J Eitler , M Rauner , VK Yadav , L Crozet , M Bohm , PL Loyher , G Karsenty , C Waskow , F Geissmann

Abstract: Nature. 2019 Apr;568(7753):541–545.In brief: Murine knockout studies unravel the developmental origin of osteoclasts in embryonic, erythro-myeloid progenitors, acquiring exceptional longevity by constant fusion with monocytes and rejuvenation of cellular nucleii throughout postnatal life.Comment: Osteoclast function is essentia...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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